ESWT Shock wave permeabilization with ribosome inactivating proteins a new approach to tumor therapy shock wave on cancer tumor

Product Description

Extracorporeal shock waves are high-pressure pulses of microsecond duration clinically used for lithotripsy. Recently, shock waves been shown to cause a transient increase of the permeability of the cell membrane. We therefore hypothesized that shock waves might be able to transfer tumoricidal agents into tumor cells and examined this in vitro and in vivo. In vitro, the ribosome inactivating proteins gelonin and saporin were transferred into L1210, SSK2, and HeLa cells, and dose-response curves were established. The drug concentration that reduced the cell proliferation by 50% (IC50) was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the enhancement factors from shock wave application were calculated. It was found that shock waves enhanced the action of gelonin from 900-fold in L1210 cells to 40,000-fold in HeLa cells and the action of saporin from 300-fold in L1210 cells to 15,000-fold in HeLa cells. In vivo, the effect of gelonin and saporin was assessed in a murine tumor model. SSK2 fibrosarcoma tumors locally grown in C3H mice were treated with shock waves after i.p. administration of gelonin or saporin. Shock wave application delayed the tumor growth, and long-term remissions lasting >180 days were induced in 40% of the animals. In conclusion, shock waves enhanced the action of ribosome inactivating proteins and led to complete tumor remissions. The local transfer of toxic substances by shock waves into tumors constitutes a new approach to a local tumor therapy.

SWs can be considered a promising technology for in vivo sonodynamic applications since they can be focused by extracorporeal device to reach different depths in the body and activate sonosensitizer leading to cancer cell death. Indeed, the strength of this therapeutic approach relies on the possibility to selectively activate the drug in situ with a subsequent improvement in drug specificity and efficacy.

For some tumor, shockwave is a good tool to eliminate the pain caused by that, and even help to reduce it, but it depends on professional guide by doctors .

BS-SWT2X Smartwave uses the latest electric-magnetic technology, without air-compressor, so comes with longer lifecycle, at the same time it can provide higher energy and frequency for better treatment result. From technical view, BS-SWT2X can reach energy from 10mJ (0.25Bar) to 190mJ (5Bar), adjustable at stepping 10mJ(0.25Bar). Frequency ranges from 1Hz to 22Hz adjustable.

From the view of transmitter, BS-SWT2X has 5 different alloy made transmitters targeting to different depth and treatment disease.It includes 6mm, 15mm, 15mm unfocused, 25mm, 36mm, which covers most applications for physical treatments as well as aesthetics treatments.

Shanghai Lumsail Medical And Beauty Equipment Co., Ltd. founded in 2007 by several rich experienced engineers, as fully invested company for science and technology in Shanghai, China, has been devoted in the field of medical equipment and aesthetics equipment for nearly 10 years. In the past ten years, Lumsail grows with its sincere customers in China, as well as in many other countries, as United States, Australia, Canada, Germany, etc. Now Lumsail has owned workshop which strictly follows ISO13485 standard, and its own research & development team, technical support team and sales team.

As leading manufacturer, LUMSAIL carries out its own brands as LUMSAIL®, SINCERY®, SMARTWAVE®, HAIRGROW® and more. More than 20 patents round new design and innovation ideas of medical and aesthetics equipments, 2 projects are awarded as Top-10 Winners of Innovation Models by China Government in 2016.

Lumsail Medical And Beauty Equipment Co., Ltd locates at Zhenru Science Park, where the largest medical and medicine center for Shanghai city at nearby, with mature upstreams for high quality components for professional medical equipment manufacturering. Now Lumsail has developed a full series of ballistic shock wave therapy equipment, from mobile type to full-standing high energy models, and other products for plastic surgical fields. By attending multiple world-class exhibitions in past decade, Lumsail has showed our products to thousands of customers all over the world.

Lumsail has been adhering to the "QUALITY FIRST, CUSTOMER FIRST, PRAGMATIC AND PIONEERING, REFINE ON" business philosophy, to provide high-quality, reasonable-cost products and first-class service to customers, rapid and harmonious development, sincerely cooperate with you, to join hands in creating a better tomorrow. Most products are CE approved, FCC approved for USA market, and part products are FDA cleared for USA market. The whole working flow is inspected by TUV from Germany to ensure our products quality, and meet the standard defined by most popular markets in European market.